Role of VLDL in Lipid Transport
VLDL is one of the crucial participants in lipid transport. It is composed of cholesterol and triglycerides. Also, it contains apolipoprotein B-100 and apolipoprotein C and E. Out of all the types of lipoproteins, it has a “very low” density due to its high lipid content. The higher the fat content in a lipoprotein, the lesser the density it has. VLDL is the primary carrier of triglycerides in cells.
Triglycerides from the small intestine and liver need to be mobilized, and this is essential for making fatty acids accessible to cells for energy generation.
VLDL carries triglycerides to cells. These are either used for energy generation or stored for future use in cells. As VLDL delivers triglycerides into the cells, the lipid composition of VLDL falls.
VLDL is responsible for the transfer of triglycerides as the source of fatty acids from the liver or small intestine to peripheral tissues.
Moreover, lipoprotein production acts as a buffer when there are excess free fatty acids in the plasma.
When the lipolysis in adipose tissue increases than the requirement of muscle and liver, the content of free fatty acids increases in plasma.
The liver produces triglycerides in VLDL from the free fatty acids it receives from adipose tissue during fasting and post-absorptive states. This is how the free fatty acid content of the plasma is balanced.
Importance of VLDL in Lipid Transport
The body needs VLDL for lipid transport and lipid metabolism. Without VLDL, lipid transport would not have been accomplished. Therefore, despite being considered one of the bad cholesterol, it plays a crucial role in lipid transport.
The effectiveness of the lipid metabolism to a greater extent depends on VLDL.
It regulates and maintains the movement of cholesterol and triglyceride inside the body.
Without VLDL, cells would not have received triglyceride as the source of fatty acids for cellular processes. Therefore, a complete lack of VLDL would have caused an absence of energy production and excess free fatty acids in plasma.
As the body’s internal environment is aqueous, VLDL offers a proper delivery system for the transport of triglycerides from the liver or small intestine to peripheral tissue.
The presence of proteins and non-fatty substances in VLDL facilitates the transport of lipids through an aqueous route (plasma) in the body. Therefore, these are highly essential in moving lipids to places where they are needed.
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